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. 2006 Sep;69(9):1347-50.
doi: 10.1021/np060156y.

Alkaloids from Gelsemium elegans

You-Kai Xu  1 , Sheng-Ping Yang, Shang-Gao Liao, Hua Zhang, Li-Ping Lin, Jian Ding, Jian-Min Yue
Affiliations

Alkaloids from Gelsemium elegans

You-Kai Xu et al. J Nat Prod. 2006 Sep.

Abstract

Three new alkaloids, gelsebanine (1), 14alpha-hydroxyelegansamine (2), and 14alpha-hydroxygelsamydine (3), and a new extraction artifact , gelsebamine (4), together with 12 known alkaloids, were isolated from the stems and leaves of Gelsemium elegans. The structures of 1-4 were determined by spectroscopic methods, especially 2D NMR techniques. Compounds 1-4 were evaluated for cytotoxic activity against four tumor cell lines, and gelsebamine (4) selectively inhibited the A-549 human lung adenocarcinoma cell line.

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