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Review
. 2006 Sep 22;126(6):1028-30.
doi: 10.1016/j.cell.2006.09.006.

Caspase-1 builds a new barrier to infection

Maya Saleh  1
Affiliations
Free article
Review

Caspase-1 builds a new barrier to infection

Maya Saleh. Cell. .
Free article

Abstract

Caspase-1 promotes both the maturation of proinflammatory cytokines and apoptosis in cells infected by certain pathogens. Work by now reveals a surprising new function for caspase-1: the stimulation of membrane biogenesis to repair damage caused by bacterial pore-forming toxins. Thus, caspase-1 may promote host cell survival as a means of resistance to pathogenic bacteria.

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