doi: 10.1039/b608544j.
Epub 2006 Aug 30.
Chemical synthesis of picornaviral protein primers of RNA replication
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- PMID: 16990933
- DOI: 10.1039/b608544j
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Chemical synthesis of picornaviral protein primers of RNA replication
Org Biomol Chem.
.
Abstract
Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg-pUpU of coxsackie virus was characterized by NMR spectroscopy.
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