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. 2006 Oct 7;4(19):3576-86.
doi: 10.1039/b608544j. Epub 2006 Aug 30.

Chemical synthesis of picornaviral protein primers of RNA replication

Nicole M A J Kriek  1 , Nico J Meeuwenoord, Hans van den Elst, Hans A Heus, Gijsbert A van der Marel, Dmitri V Filippov
Affiliations

Chemical synthesis of picornaviral protein primers of RNA replication

Nicole M A J Kriek et al. Org Biomol Chem. .

Abstract

Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg-pUpU of coxsackie virus was characterized by NMR spectroscopy.

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