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. 1975 Jul;54(3):339-49.
doi: 10.1111/j.1476-5381.1975.tb07574.x.

An inhibitory effect of atropine on responses of the vas deferens of the mouse to field stimulation

M E Jones, T L Spriggs

An inhibitory effect of atropine on responses of the vas deferens of the mouse to field stimulation

M E Jones et al. Br J Pharmacol. 1975 Jul.

Abstract

1 Atropine is shown to impair responses of the vas deferens of the mouse to field stimulation by acting at a site proximal to the smooth muscle cells. 2 The inhibitory effect of atropine is prevented by desmethylimipramine and reversed by dexamphetamine, and appears similar to the adrenergic-neurone blockade of guanethidine. 3 Electronmicroscopical studies show the presence in vas of presumptive noradrenergic axons which have acetylcholinesterase reaction product associated with their axolemmae. 4 These results are discussed in relation to the controversial hypothesis of a 'cholinergic link' in noradrenergic transmission.

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