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. 1990 Oct;178(2):631-4.
doi: 10.1016/0042-6822(90)90368-2.

Antigenic mimicry of an immunoglobulin A epitope by a hepatitis B virus cell attachment site

A R Neurath  1 , N Strick
Affiliations

Antigenic mimicry of an immunoglobulin A epitope by a hepatitis B virus cell attachment site

A R Neurath et al. Virology. 1990 Oct.

Abstract

The preS(21-47) sequence of the hepatitis B virus (HBV) envelope protein is involved in binding of the virus to cell receptors. A protein similarity search revealed a partial homology between this sequence and a segment of the human immunoglobulin A (IgA) heavy chain constant region, suggesting that the cell attachment site for HBV might be located on secretory component representing a receptor for polymeric IgA. Data presented herein do not support this hypothesis but provide evidence for immunological cross-reactivity between IgA and the preS(21-47) region of the HBV env protein.

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