Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study Group
- PMID: 1699513
- DOI: 10.1001/archopht.1990.01070120090035
Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study Group
Abstract
We graded macular features of 127 fellow eyes of participants in the Macular Photocoagulation Study who had an extrafoveal choroidal neovascular membrane secondary to age-related macular degeneration in the first eye and no initial evidence of the neovascular form of age-related macular degeneration in the fellow eye. Our aims were to determine the relationship of drusen characteristics and retinal pigment epithelial abnormalities to the risk of subsequent development of neovascularization in the fellow eye and the risk of subsequent development of recurrent neovascular membranes after photocoagulation in the first eye. Regression analysis demonstrated that the presence of large drusen and focal hyperpigmentation of the retinal pigment epithelium were independent risk factors for the subsequent development of neovascularization in the fellow eye (relative risk, 2.4 and 2.5, respectively). Only 10% of eyes with no large drusen or any retinal pigment epithelial hyperpigmentation compared with 58% of eyes with both large drusen and retinal pigment epithelial hyperpigmentation developed neovascularization in the fellow eye within 5 years. Using multivariate Cox regression analysis, we noted that the risk of developing recurrent neovascular membranes in the first eye was significantly increased when large drusen (relative risk, 2.8) were noted in the fellow eye at the time of laser treatment in the first eye. Fundus features in the fellow eye appear to help identify patients at high risk of developing visual loss from recurrent neovascular membranes following laser treatment in the first eye and from development of a neovascular membrane in the fellow eye.
Similar articles
-
Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities. Waterman study.Arch Ophthalmol. 1995 Mar;113(3):301-8. doi: 10.1001/archopht.1995.01100030055022. Arch Ophthalmol. 1995. PMID: 7534060
-
Laser treatment in eyes with large drusen. Short-term effects seen in a pilot randomized clinical trial. Choroidal Neovascularization Prevention Trial Research Group.Ophthalmology. 1998 Jan;105(1):11-23. Ophthalmology. 1998. PMID: 9442774 Clinical Trial.
-
Laser photocoagulation for macular soft drusen. Updated results.Retina. 1997;17(5):378-84. doi: 10.1097/00006982-199709000-00004. Retina. 1997. PMID: 9355184 Clinical Trial.
-
Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression.Surv Ophthalmol. 1999 Jul-Aug;44(1):1-29. doi: 10.1016/s0039-6257(99)00072-7. Surv Ophthalmol. 1999. PMID: 10466585 Review.
-
[Drusen in Bruch's membrane. Their significance for the pathogenesis and therapy of age-associated macular degeneration].Ophthalmologe. 1992 Oct;89(5):363-86. Ophthalmologe. 1992. PMID: 1304217 Review. German.
Cited by
-
Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: a prospective study.Graefes Arch Clin Exp Ophthalmol. 2005 Apr;243(4):300-5. doi: 10.1007/s00417-004-1027-3. Epub 2004 Oct 13. Graefes Arch Clin Exp Ophthalmol. 2005. PMID: 15864618
-
Age-related macular degeneration and changes in the extracellular matrix.Med Sci Monit. 2014 Jun 18;20:1003-16. doi: 10.12659/MSM.889887. Med Sci Monit. 2014. PMID: 24938626 Free PMC article. Review.
-
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.Arch Ophthalmol. 2001 Oct;119(10):1417-36. doi: 10.1001/archopht.119.10.1417. Arch Ophthalmol. 2001. PMID: 11594942 Free PMC article. Clinical Trial.
-
Drusen analysis in a human-machine synergistic framework.Arch Ophthalmol. 2011 Jan;129(1):40-7. doi: 10.1001/archophthalmol.2010.328. Arch Ophthalmol. 2011. PMID: 21220627 Free PMC article.
-
Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration.Int J Inflam. 2013;2013:503725. doi: 10.1155/2013/503725. Epub 2013 Mar 7. Int J Inflam. 2013. PMID: 23533946 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical