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Review
. 2006;5(3):220-6.
doi: 10.1080/14734220600621344.

Activity-dependent modulation of inhibition in Purkinje cells by TrkB ligands

Rosemarie Drake-Baumann  1
Affiliations
Review

Activity-dependent modulation of inhibition in Purkinje cells by TrkB ligands

Rosemarie Drake-Baumann. Cerebellum. 2006.

Abstract

In the cerebellum in vitro TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis of Purkinje cells and also modulate inhibitory synaptic function. This mini review examines the roles of TrkB receptor activation by BDNF particularly in relation to activity-dependent synaptic plasticity on Purkinje cells and recent studies on the acute modulation of GABAergic synapses by BDNF.

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