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Review
. 2006 Jul;84(7):667-75.
doi: 10.1139/y06-012.

PTP1B and TC-PTP: novel roles in immune-cell signaling

Paul D Simoncic  1 , C Jane McGlade, Michel L Tremblay
Affiliations
Review

PTP1B and TC-PTP: novel roles in immune-cell signaling

Paul D Simoncic et al. Can J Physiol Pharmacol. 2006 Jul.

Abstract

It has recently been demonstrated that the protein tyrosine phosphatase (PTP) PTP1B and the T-cell PTP (TC-PTP) target several substrates involved in immune cell signaling. Recent data have furthered the view of these 2 PTP members as key regulators of the immune response. This review will focus on the substrate specificities of PTP1B and TC-PTP and their roles in immune cell signaling, and will discuss some new data implicating PTP1B and TC-PTP in myeloid development.

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