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Review
. 2006 Oct;62(Pt 10):1137-49.
doi: 10.1107/S090744490602943X. Epub 2006 Sep 19.

SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance analysis, new technologies and future aspects

Ian M Berry  1 , O Dym, R M Esnouf, K Harlos, R Meged, A Perrakis, J L Sussman, T S Walter, J Wilson, Albrecht Messerschmidt
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Free article
Review

SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance analysis, new technologies and future aspects

Ian M Berry et al. Acta Crystallogr D Biol Crystallogr. 2006 Oct.
Free article

Abstract

This paper reviews the developments in high-throughput and nanolitre-scale protein crystallography technologies within the remit of workpackage 4 of the Structural Proteomics In Europe (SPINE) project since the project's inception in October 2002. By surveying the uptake, use and experience of new technologies by SPINE partners across Europe, a picture emerges of highly successful adoption of novel working methods revolutionizing this area of structural biology. Finally, a forward view is taken of how crystallization methodologies may develop in the future.

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