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Review
. 2006 Dec;22(12):945-59.
doi: 10.1007/s00383-006-1782-9.

Enteric nervous system and developmental abnormalities in childhood

Thambipillai Sri Paran  1 , Udo Rolle, Prem Puri
Affiliations
Review

Enteric nervous system and developmental abnormalities in childhood

Thambipillai Sri Paran et al. Pediatr Surg Int. 2006 Dec.

Abstract

ENS consists of a complex network of neurons, organised in several plexuses, which interact by means of numerous neurotransmitters. It is capable of modulating the intestinal motility, exocrine and endocrine secretions, microcirculation and immune and inflammatory responses within the gastrointestinal tract, independent of the central nervous system. Though the embryological development of various plexuses are completed by mid-way of gestation, the maturation of neurons and nerve plexuses appear to continue well after birth. Therefore, any histological or functional abnormalities related to the gastrointestinal function must be investigated with the ongoing maturational processes in mind.

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