Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Oct 3;103(40):14651-2.
doi: 10.1073/pnas.0607135103. Epub 2006 Sep 26.

Imatinib spells BAD news for Bcr/abl-positive leukemias

Scott H Kaufmann  1
Affiliations
Comment

Imatinib spells BAD news for Bcr/abl-positive leukemias

Scott H Kaufmann. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Schematic representation of Bcr/abl-mediated survival signaling. Bcr/abl activates several signal transduction pathways that are known to inhibit apoptosis. Bcl-2 family members shown by Kuroda et al. (5) to affect imatinib sensitivity are enclosed in yellow boxes. Activating protein–protein interactions or phosphorylations are indicated by black arrows, activating protein–protein interactions are indicated by black bars, inactivating phosphorylation events are indicated by red bars, and transcriptional activation events are indicated by green arrows.
See this image and copyright information in PMC

Comment on

References

    1. Deininger MW, Druker BJ. Pharmacol Rev. 2003;55:401–423. - PubMed
    1. Shah NP, Sawyers CL. Oncogene. 2003;22:7389–7395. - PubMed
    1. Druker BJ. N Engl J Med. 2006;354:2594–2596. - PubMed
    1. Deininger MW, Buchdunger E, Drucker BJ. Blood. 2005;105:2640–2653. - PubMed
    1. Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DCS, Kimura S, Ottmann OG, Druker BJ, Villunger A, et al. Proc Natl Acad Sci USA. 2006;103:14907–14912. - PMC - PubMed

MeSH terms