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. 2006 Nov;44(11):4242-5.
doi: 10.1128/JCM.01558-06. Epub 2006 Sep 27.

Integrons containing the VIM-2 metallo-beta-lactamase gene among imipenem-resistant Pseudomonas aeruginosa strains from different Chinese hospitals

Yun-Song Yu  1 , Ting-Ting Qu, Jian-Ying Zhou, Jie Wang, Hong-Yang Li, Timothy R Walsh
Affiliations

Integrons containing the VIM-2 metallo-beta-lactamase gene among imipenem-resistant Pseudomonas aeruginosa strains from different Chinese hospitals

Yun-Song Yu et al. J Clin Microbiol. 2006 Nov.

Abstract

A total of 140 nonrepetitive strains of imipenem-resistant Pseudomonas aeruginosa were isolated from five different Chinese hospitals. Fourteen isolates were confirmed to contain the VIM-2 metallo-beta-lactamase gene. Twelve isolates harbored two kinds of class 1 integron, containing both VIM-2- and aminoglycoside-resistant genes.

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Figures

FIG. 1.
FIG. 1.
Locations of the five cities in China involved in this study.
FIG. 2.
FIG. 2.
Schematic integron structures (not to scale) of integrons in isolates P. aeruginosa B2, B3, B28, H19, H26, H54, and G4 (A) and P. aeruginosa S5, S9, S10, S11, and S12 (B). These integrons had approximate sizes of 2.5 and 3 kb, respectively. The open reading frames are shown as arrows, which also indicate their transcriptional orientations.
FIG. 3.
FIG. 3.
Southern hybridization analysis of the XbaI-digested chromosomal DNA fragments from the 14 strains containing the blaVIM-2 gene. PFGE patterns (A) are shown. M, lambda molecular weight ladder. (B) Results from Southern hybridization using a blaVIM-2 DNA probe.
See this image and copyright information in PMC

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