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Review
. 2006 Nov 15;54(7):700-715.
doi: 10.1002/glia.20367.

Vesicular transmitter release from astrocytes

Vedrana Montana  1 , Erik B Malarkey  1 , Claudia Verderio  2 , Michela Matteoli  2 , Vladimir Parpura  1
Affiliations
Review

Vesicular transmitter release from astrocytes

Vedrana Montana et al. Glia. .

Abstract

Astrocytes can release a variety of transmitters, including glutamate and ATP, in response to stimuli that induce increases in intracellular Ca(2+) levels. This release occurs via a regulated, exocytotic pathway. As evidence of this, astrocytes express protein components of the vesicular secretory apparatus, including synaptobrevin 2, syntaxin, and SNAP-23. Additionally, astrocytes possess vesicular organelles, the essential morphological elements required for regulated Ca(2+)-dependent transmitter release. The location of specific exocytotic sites on these cells, however, remains to be unequivocally determined.

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References

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