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. 1990 Sep 15;270(3):833-6.
doi: 10.1042/bj2700833.

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat

R G Knowles  1 , M Merrett, M Salter, S Moncada
Affiliations

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat

R G Knowles et al. Biochem J. .

Abstract

Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.

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