doi: 10.1042/bj2700833.
Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat
Affiliations
- PMID: 1700698
- PMCID: PMC1131810
- DOI: 10.1042/bj2700833
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Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat
Biochem J.
.
Abstract
Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.
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