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. 2006 Sep 14;12(34):5473-8.
doi: 10.3748/wjg.v12.i34.5473.

-765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia

Carina Pereira  1 , Hugo Sousa, Paula Ferreira, Maria Fragoso, Luís Moreira-Dias, Carlos Lopes, Rui Medeiros, Mário Dinis-Ribeiro
Affiliations

-765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia

Carina Pereira et al. World J Gastroenterol. .

Abstract

Aim: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma.

Methods: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method.

Results: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).

Conclusion: -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.

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Figures

Figure 1
Figure 1
PCR-RFLP analysis of -765G > C COX-2 polymorphism. M: 50 bp DNA ladder; 1: Homozygous -765CC genotype; 2, 3: Heterozygous -765GC genotype; 4: Homozygous -765GG genotype.
See this image and copyright information in PMC

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