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Comparative Study
. 2006:16 Suppl 2:552-5.
doi: 10.1111/j.1525-1438.2006.00694.x.

Association between the CHEK2*1100delC germ line mutation and estrogen receptor status

G H de Bock  1 , M J E Mourits, M Schutte, E M M Krol-Warmerdam, C Seynaeve, J Blom, C T M Brekelmans, H Meijers-Heijboer, C J van Asperen, C J Cornelisse, P Devilee, R A E M Tollenaar, J G M Klijn
Affiliations
Comparative Study

Association between the CHEK2*1100delC germ line mutation and estrogen receptor status

G H de Bock et al. Int J Gynecol Cancer. 2006.

Abstract

Already published data were further analyzed regarding the association between the CHEK2*1100delC germ line mutation and estrogen receptor (ER) status in patients with breast cancer. The CHEK2*1100delC mutation was more prevalent among the patients with a positive ER status (4.2% versus 1.0%). An ER-negative status was beside CHEK2*1100delC mutation and independently associated with an earlier of age onset of breast cancer. There was a trend that an ER-negative status, beside the presence of a CHEK2*1100delC mutation, was associated with a worse disease-free survival. There might be an association between ER status and a CHEK2*1100delC mutation. More studies with larger number of patients are needed to further investigate the relation between CHEK2*1100delC and ER status.

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