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. 1990 Dec;10(12):6755-8.
doi: 10.1128/mcb.10.12.6755-6758.1990.

Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells

B R Stanton  1 , S W Reid, L F Parada
Affiliations

Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells

B R Stanton et al. Mol Cell Biol. 1990 Dec.

Abstract

We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development.

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