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. 1990 Nov 29;348(6300):411-8.
doi: 10.1038/348411a0.

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

J H Wang  1 , Y W Yan, T P Garrett, J H Liu, D W Rodgers, R L Garlick, G E Tarr, Y Husain, E L Reinherz, S C Harrison
Affiliations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

J H Wang et al. Nature. .

Abstract

The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.

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Comment in

  • Immunology. One hand clapping.
    Travers P. Travers P. Nature. 1990 Nov 29;348(6300):393-4. doi: 10.1038/348393a0. Nature. 1990. PMID: 2247144 No abstract available.

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