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. 2006 Dec;86(6):1736-43.
doi: 10.1016/j.fertnstert.2006.05.047. Epub 2006 Sep 29.

Characterization of estrogen receptors alpha and beta in uterine leiomyoma cells

Francisco Valladares  1 , Ignacio Frías, Delia Báez, Candelaria García, Francisco J López, James D Fraser, Yurena Rodríguez, Ricardo Reyes, Lucio Díaz-Flores, Aixa R Bello
Affiliations
Free article

Characterization of estrogen receptors alpha and beta in uterine leiomyoma cells

Francisco Valladares et al. Fertil Steril. 2006 Dec.
Free article

Abstract

Objective: Cellular and subcellular localization of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) in uterine leiomyomas.

Design: Retrospective study.

Setting: University of La Laguna (ULL) and Canary University Hospital (HUC).

Patient(s): Premenopausal and postmenopausal women with uterine leiomyomas.

Intervention(s): Hysterectomy and myomectomy.

Result(s): Estrogen receptor alpha was only present in smooth muscle cells with variation in the subcellular location in different leiomyomas. Estrogen receptor beta was widely distributed in smooth muscle, endothelial, and connective tissue cells with nuclear location in all cases studied; variations were only found in the muscle cells for this receptor.

Conclusion(s): Estrogens operate in leiomyoma smooth muscle cells through different receptors, alpha and beta. However they only act through the ERbeta in endothelial and connective cells.

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