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Randomized Controlled Trial
. 2006 Sep-Oct;68(5):734-41.
doi: 10.1097/01.psy.0000234029.38245.c9.

Effects of naltrexone on repressive coping and disclosure of emotional material: a test of the opioid-peptide hypothesis of repression and hypertension

Jarred W Younger  1 , Kathleen A Lawler-Row, Krista A Moe, Anna L Kratz, Amy J Keenum
Affiliations
Randomized Controlled Trial

Effects of naltrexone on repressive coping and disclosure of emotional material: a test of the opioid-peptide hypothesis of repression and hypertension

Jarred W Younger et al. Psychosom Med. 2006 Sep-Oct.

Abstract

Objective: The present study was designed to assess the role of endogenous opioids in the relationship of hypertension to repressive coping.

Methods: Ten hypertensive and 8 normotensive males were given either the opioid antagonist naltrexone or placebo in a randomized, double-blind fashion over the course of four laboratory sessions. Measures of repression and disclosure were completed and blood pressure was assessed during a laboratory stressor protocol.

Results: Opioid antagonism reduced repression and increased disclosure only in the hypertensive group. Also, opioid antagonism increased stress-related systolic blood pressure only in the hypertensive group.

Conclusion: The results support the hypothesis that endogenous opioid dysregulation underlies both hypertension and repressive phenomena.

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