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. 2006 Oct:189:381-2.
doi: 10.1192/bjp.bp.105.015701.

Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

W Cahn  1 , N E M van Haren, H E Hulshoff Pol, H G Schnack, E Caspers, D A J Laponder, R S Kahn
Affiliations

Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

W Cahn et al. Br J Psychiatry. 2006 Oct.

Abstract

Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia.

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