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. 1990 Nov 23;250(4984):1130-2.
doi: 10.1126/science.1701274.

ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex

M L Phillips  1 , E Nudelman, F C Gaeta, M Perez, A K Singhal, S Hakomori, J C Paulson
Affiliations

ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex

M L Phillips et al. Science. .

Abstract

Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc alpha 2,3Gal beta 1,4(Fuc alpha 1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.

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