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Comment
. 2006 Nov;149(6):609-10.
doi: 10.1038/sj.bjp.0706907. Epub 2006 Oct 3.

What is the significance of vascular hydrogen sulphide (H2S)?

S E O'Sullivan  1
Affiliations
Comment

What is the significance of vascular hydrogen sulphide (H2S)?

S E O'Sullivan. Br J Pharmacol. 2006 Nov.

Abstract

The important role of nitric oxide (NO) in the regulation of vascular tone has been well studied. By contrast, the vascular significance of another gaseous mediator, hydrogen sulphide (H2S), is still poorly understood. A study published in this issue of the British Journal of Pharmacology now provides evidence that in addition to the vasorelaxant effects of H2S reported in vitro, low concentrations of H2S also cause arterial vasoconstriction, reverse NO-mediated vasorelaxation and cause an NO-dependent pressor effect in vivo. This commentary discusses the implications and questions raised by these results.

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References

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