Driving actin dynamics under the influence of alcohol
- PMID: 17018272
- DOI: 10.1016/j.cell.2006.09.017
Driving actin dynamics under the influence of alcohol
Abstract
The actin cytoskeleton plays a pivotal role in regulating neuronal development and activity, and dysregulation of actin dynamics has been linked to impaired cognitive function. In this issue of Cell Rothenfluh et al. (2006) , and Offenhäuser et al. (2006) show that actin dynamics can also affect the cellular and behavioral responses of flies and mice to alcohol.
Comment on
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Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms.Cell. 2006 Oct 6;127(1):199-211. doi: 10.1016/j.cell.2006.09.010. Cell. 2006. PMID: 17018286
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Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.Cell. 2006 Oct 6;127(1):213-26. doi: 10.1016/j.cell.2006.09.011. Cell. 2006. PMID: 17018287
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