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Comment
. 2006 Oct 6;127(1):42-4.
doi: 10.1016/j.cell.2006.09.019.

RalB signaling: a bridge between inflammation and cancer

Alberto Mantovani  1 , Frances Balkwill
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RalB signaling: a bridge between inflammation and cancer

Alberto Mantovani et al. Cell. .
Free article

Abstract

A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has been established. In this issue, Chien et al. (2006) show that the RalB GTPase regulates the IKK family member TBK1, providing an unexpected link between the signaling pathways that promote inflammation and cancer. In tumor cells the RalB/TBK1 pathway inhibits apoptosis and in nontumorigenic cells it stimulates an innate immune response.

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