doi: 10.1038/348699a0.
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
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- PMID: 1701851
- DOI: 10.1038/348699a0
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A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
Nature.
1990 Dec.
Abstract
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.
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