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. 2006 Nov;96(11):1979-88.
doi: 10.2105/AJPH.2005.083014. Epub 2006 Oct 3.

Ashkenazi Jews and breast cancer: the consequences of linking ethnic identity to genetic disease

Sherry I Brandt-Rauf  1 , Victoria H Raveis, Nathan F Drummond, Jill A Conte, Sheila M Rothman
Affiliations

Ashkenazi Jews and breast cancer: the consequences of linking ethnic identity to genetic disease

Sherry I Brandt-Rauf et al. Am J Public Health. 2006 Nov.

Abstract

We explored the advantages and disadvantages of using ethnic categories in genetic research. With the discovery that certain breast cancer gene mutations appeared to be more prevalent in Ashkenazi Jews, breast cancer researchers moved their focus from high-risk families to ethnicity. The concept of Ashkenazi Jews as genetically unique, a legacy of Tay-Sachs disease research and a particular reading of history, shaped this new approach even as methodological imprecision and new genetic and historical research challenged it. Our findings cast doubt on the accuracy and desirability of linking ethnic groups to genetic disease. Such linkages exaggerate genetic differences among ethnic groups and lead to unequal access to testing and therapy.

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References

    1. Smedley A, Smedly BD. Race as biology is fiction, racism as a social problem is real: anthropological and historical perspectives on the social construction of race. Am Psychol. 2005;60:16–26. - PubMed
    1. Barkan E. The Retreat of Scientific Racism: Changing Concepts of Race in Britain and the United States Between the World Wars. Cambridge, England: Cambridge University Press; 1992.
    1. Reardon J. Race to the Finish: Identity and Governance in an Age of Genomics. Princeton, NJ: Princeton University Press; 2005.
    1. Goodman RM. Genetic Disorders Among the Jewish People. Baltimore, Md: Johns Hopkins University Press; 1979.
    1. Motulsky AG. Jewish diseases and origins. Nat Genet. 1995;9:99–101. - PubMed

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