Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Sep;12(3):521-7.
doi: 10.1128/iai.12.3.521-527.1975.

Candidate cytomegalovirus strain for human vaccination

S A Plotkin, T Furukawa, N Zygraich, C Huygelen

Candidate cytomegalovirus strain for human vaccination

S A Plotkin et al. Infect Immun. 1975 Sep.

Abstract

A strain of human cytomegalovirus called Towne was isolated in WI-38 human fibrolast cell cultures from the urine of an infected infant. It was then passaged 125 times in WI-38, including three clonings, and a pool was prepared in the same cell substrate for use as a potential live attenuated vaccine. The Towne virus has a broad antigenicity and cross-reacts with the AD-169 strain. Several markers of the Towne virus were found which differentiated it from fresh isolates. One of these was resistance of the former to trypsin. The Towne virus was tested for freedom from oncogenicity or other harmful effects in preparation for tests in humans.

PubMed Disclaimer

References

    1. Am Heart J. 1966 Jul;72(1):116-23 - PubMed
    1. J Gen Virol. 1969 Jun;4(4):557-64 - PubMed
    1. Infect Immun. 1971 Jan;3(1):159-63 - PubMed
    1. Infect Immun. 1971 Feb;3(2):228-36 - PubMed
    1. Infection. 1975;3(2):111-4 - PubMed

LinkOut - more resources