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. 2006 Dec;44(12):4559-60.
doi: 10.1128/JCM.01440-06. Epub 2006 Oct 4.

Combined hepatitis C virus (HCV) antigen-antibody detection assay does not improve diagnosis for seronegative individuals with occult HCV infection

Juan A Quiroga  1 , Inmaculada Castillo, Margarita Pardo, Elena Rodríguez-Iñigo, Vicente Carreño
Affiliations

Combined hepatitis C virus (HCV) antigen-antibody detection assay does not improve diagnosis for seronegative individuals with occult HCV infection

Juan A Quiroga et al. J Clin Microbiol. 2006 Dec.

Abstract

A combined hepatitis C virus (HCV) antigen-antibody assay was evaluated for 115 seronegative individuals with occult HCV infection. The assay was reactive in one patient and negative to weakly reactive in three others (all four gave indeterminate results by supplemental assay) but failed to detect HCV in the remaining patients. Despite increased sensitivity the combined assay does not improve serodiagnosis of occult HCV infection.

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Figures

FIG. 1.
FIG. 1.
Time course of SCO ratios of sequential serum samples tested by Monolisa HCV Ag-Ab Ultra assay in two patients with occult HCV infection. Squares, patient no. 1; circles, patient no. 3 (Table 1). Horizontal lines denote thresholds for detection set at SCO of 1 (upper line) and 0.5 (lower line).
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References

    1. Ansaldi, F., B. Bruzzone, G. Testino, M. Bassetti, R. Gasparini, P. Crovari, and G. Icardi. 2006. Combination hepatitis C virus antigen and antibody immunoassay as a new tool for early diagnosis of infection. J. Viral Hepat. 13:5-10. - PubMed
    1. Castillo, I., M. Pardo, J. Bartolomé, N. Ortiz-Movilla, E. Rodríguez-Iñigo, S. de Lucas, C. Salas, J. A. Jiménez-Hefferman, A. Pérez-Mota, J. Graus, J. M. López-Alcorocho, and V. Carreño. 2004. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J. Infect. Dis. 189:7-14. - PubMed
    1. Castillo, I., E. Rodríguez-Iñigo, J. Bartolomé, S. de Lucas, N. Ortíz-Movilla, J. M. López-Alcorocho, M. Pardo, and V. Carreño. 2005. Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection. Gut 54:682-685. - PMC - PubMed
    1. Laperche, S., N. Le Marrec, A. Girault, F. Bouchardeau, A. Servant-Delmas, M. Maniez-Montreuil, P. Gallian, T. Levayer, P. Morel, and N. Simon. 2005. Simultaneous detection of hepatitis C virus (HCV) core antigen and anti-HCV antibodies improves the early detection of HCV infection. J. Clin. Microbiol. 43:3877-3883. - PMC - PubMed
    1. Laperche, S., M. H. Elghouzzi, P. Morel, M. Asso-Bonnet, N. Le Marrec, A. Girault, A. Servant-Delmas, F. Bouchardeau, M. Deschaseaux, and Y. Piquet. 2005. Is an assay for simultaneous detection of hepatitis C virus core antigen and antibody a valuable alternative to nucleic acid testing? Transfusion 45:1965-1972. - PubMed

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