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. 2006 Dec;44(12):4559-60.
doi: 10.1128/JCM.01440-06. Epub 2006 Oct 4.

Combined hepatitis C virus (HCV) antigen-antibody detection assay does not improve diagnosis for seronegative individuals with occult HCV infection

Juan A Quiroga  1 , Inmaculada Castillo, Margarita Pardo, Elena Rodríguez-Iñigo, Vicente Carreño
Affiliations

Combined hepatitis C virus (HCV) antigen-antibody detection assay does not improve diagnosis for seronegative individuals with occult HCV infection

Juan A Quiroga et al. J Clin Microbiol. 2006 Dec.

Abstract

A combined hepatitis C virus (HCV) antigen-antibody assay was evaluated for 115 seronegative individuals with occult HCV infection. The assay was reactive in one patient and negative to weakly reactive in three others (all four gave indeterminate results by supplemental assay) but failed to detect HCV in the remaining patients. Despite increased sensitivity the combined assay does not improve serodiagnosis of occult HCV infection.

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Figures

FIG. 1.
FIG. 1.
Time course of SCO ratios of sequential serum samples tested by Monolisa HCV Ag-Ab Ultra assay in two patients with occult HCV infection. Squares, patient no. 1; circles, patient no. 3 (Table 1). Horizontal lines denote thresholds for detection set at SCO of 1 (upper line) and 0.5 (lower line).
See this image and copyright information in PMC

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