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. 2006 Dec;44(12):4547-9.
doi: 10.1128/JCM.01611-06. Epub 2006 Oct 4.

Assessing the genetic diversity of the aldolase genes of Plasmodium falciparum and Plasmodium vivax and its potential effect on performance of aldolase-detecting rapid diagnostic tests

Nelson Lee  1 , Joanne Baker, David Bell, James McCarthy, Qin Cheng
Affiliations

Assessing the genetic diversity of the aldolase genes of Plasmodium falciparum and Plasmodium vivax and its potential effect on performance of aldolase-detecting rapid diagnostic tests

Nelson Lee et al. J Clin Microbiol. 2006 Dec.

Abstract

Malaria-specific rapid diagnostic tests (RDTs) targeting aldolase show highly variable sensitivities. We assessed diversity in Plasmodium falciparum and P. vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity.

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References

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