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. 2006 Oct;44(10):3781-3.
doi: 10.1128/JCM.01249-06.

Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa

Anna R Thorner  1 , Ronald Vogels, Jorn Kaspers, Gerrit J Weverling, Lennart Holterman, Angelique A C Lemckert, Athmanundh Dilraj, Lisa M McNally, Prakash M Jeena, Soren Jepsen, Peter Abbink, Anjali Nanda, Patricia E Swanson, Andrew T Bates, Kara L O'Brien, Menzo J E Havenga, Jaap Goudsmit, Dan H Barouch
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Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa

Anna R Thorner et al. J Clin Microbiol. 2006 Oct.

Abstract

We assessed neutralizing antibody titers to adenovirus serotype 5 (Ad5) and six rare adenovirus serotypes, serotypes 11, 35, 50, 26, 48, and 49, in pediatric populations in sub-Saharan Africa. We observed a clear age dependence of Ad5-specific neutralizing antibody titers. These data will help to guide the development of Ad vector-based vaccines for human immunodeficiency virus type 1 and other pathogens.

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Figures

FIG. 1.
FIG. 1.
Ad5 NAbs in paired mother-infant samples. Ad5 NAb titers were assessed in 42 serum samples from mothers and infants. Concordance of NAb titers between mothers and infants is shown both as a scatter plot (left) and as box-and-whisker plots (right).
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