Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2007 May;26(5):845-8.
doi: 10.1007/s10067-006-0419-7. Epub 2006 Oct 5.

Influence of intraarticular corticosteroid administration on serum cytokines in rheumatoid arthritis

Philip Alex  1 , Peter Szodoray, Eugene Arthur, Larry Willis, Robert Hynd, Don Flinn, Michael Centola
Affiliations
Case Reports

Influence of intraarticular corticosteroid administration on serum cytokines in rheumatoid arthritis

Philip Alex et al. Clin Rheumatol. 2007 May.

Abstract

Though the efficacy of intraarticular (IA) corticosteroid administration in the therapeutic management of rheumatoid arthritis (RA) has been well documented, its immunomodulatory effects have not been defined. Categorization of these effects is important to develop safe derivative therapeutic strategies with a more targeted mechanism of action as they relate to the pathophysiology of RA. We describe here a broad spectrum immune response to inflammation as evidenced by rapid transient systemic inhibitory effects on key inflammatory regulators induced by the effects of IA administration of triamcinolone acetonide in a case of active RA who failed to respond to methotrexate.

PubMed Disclaimer

References

    1. J Rheumatol. 2004 Dec;31(12):2336-46 - PubMed
    1. J Clin Invest. 2004 Feb;113(4):619-27 - PubMed
    1. Rheumatology (Oxford). 1999 Feb;38(2):95-7 - PubMed
    1. Int Immunol. 1999 Jul;11(7):1139-47 - PubMed
    1. Semin Arthritis Rheum. 1981 May;10(4):231-54 - PubMed

Publication types

LinkOut - more resources