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Review
. 1991 Jan 5;337(8732):25-7.
doi: 10.1016/0140-6736(91)93341-6.

FK 506: an immunosuppressant for the 1990s?

A M Macleod  1 , A W Thomson
Affiliations
Review

FK 506: an immunosuppressant for the 1990s?

A M Macleod et al. Lancet. .

Erratum in

  • Lancet 1991 Apr 13;337(8746):928

Abstract

The novel macrolide immunosuppressant FK 506 is a powerful and selective anti-T-cell agent which has a similar mode of action to that of cyclosporin. Clinical studies of FK 506 in liver allograft recipients indicate a lower risk/benefit ratio than with cyclosporin, and wider evaluation of FK 506 in transplant recipients is now under way in multicentre, prospective, controlled trials in both Europe and North America.

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Comment in

  • Mechanism of action of FK 506 and cyclosporin.
    Steinmann B, Superti-Furga A, Bruckner P. Steinmann B, et al. Lancet. 1991 Feb 16;337(8738):439. doi: 10.1016/0140-6736(91)91225-j. Lancet. 1991. PMID: 1704088 No abstract available.
  • FK 506.
    Sewing KF, Christians U. Sewing KF, et al. Lancet. 1991 Feb 23;337(8739):499. doi: 10.1016/0140-6736(91)93441-b. Lancet. 1991. PMID: 1704090 No abstract available.

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