doi: 10.1002/ijc.2910160403.
Transformation of mouse cells after infection with ultraviolet irradiation-inactivated herpes simplex virus type 2
- PMID: 170223
- DOI: 10.1002/ijc.2910160403
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Transformation of mouse cells after infection with ultraviolet irradiation-inactivated herpes simplex virus type 2
Int J Cancer.
.
Abstract
A transformed mouse cell line (H238) was obtained following the infection of 238 mouse cells with ultraviolet (UV) irradiation-inactivated herpes simplex virus type 2 (HSV-2). The transformed cells produced tumors with a 100% incidence within 8 weeks in 6-week-old syngeneic BALB/c mice at an inoculum of 1 times 10(6). Indirect immunofluorescence (IF) tests revealed the presence of HSV antigens in the transformed cells. Antibodies to HSV-2 were found in the sera of tumor-bearing animals by neutralization and IF techniques. Neither HSV-2 infectious virus nor viral antigens could be detected by the transfer of transformed-cell DNA into permissive cells.
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