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. 1990 Dec;65(6):791-5.
doi: 10.1093/bja/65.6.791.

Use of the calcium agonist BAY K 8644 for in vitro diagnosis of susceptibility to malignant hyperthermia

P J Adnet  1 , R M Krivosic-Horber, G Haudecoeur, M M Adamantidis, G H Reyford, M Imbenotte, C Cordonnier
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Free article

Use of the calcium agonist BAY K 8644 for in vitro diagnosis of susceptibility to malignant hyperthermia

P J Adnet et al. Br J Anaesth. 1990 Dec.
Free article

Abstract

We have studied the effects of the calcium agonist BAY K 8644 on the in vitro halothane test in 10 malignant hyperthermia-susceptible (MHS), 12 MH "equivocal" to halothane (MHEh), 30 MH non-susceptible (MHN) and 10 control patients. BAY K 8644 potentiated the halothane-induced contracture in muscle strips from both MHS and MHEh patients. The drug produced a more obvious difference in contracture responses between the MHEh group compared with the MHN and control groups.

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