Regulation of ENaCs by proteases: An increasingly complex story
- PMID: 17024162
- DOI: 10.1038/sj.ki.5001860
Regulation of ENaCs by proteases: An increasingly complex story
Abstract
Proteolytic processing of epithelial Na+ channel (ENaC) subunits has an important role in the regulation of ENaC gating. This Commentary addresses the potential roles of specific proteases and protease inhibitors in the control of Na+ channel gating.
Comment on
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Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone.Kidney Int. 2006 Oct;70(8):1432-8. doi: 10.1038/sj.ki.5001787. Epub 2006 Aug 30. Kidney Int. 2006. PMID: 16941024
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