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. 2006 Oct 21;4(20):3778-84.
doi: 10.1039/b608213k. Epub 2006 Aug 31.

Conformational analogues of Oxamflatin as histone deacetylase inhibitors

Anthony E Dear  1 , Hong B Liu, Penelope A Mayes, Patrick Perlmutter
Affiliations

Conformational analogues of Oxamflatin as histone deacetylase inhibitors

Anthony E Dear et al. Org Biomol Chem. .

Abstract

Conformational analogues of the hydroxamic acid Oxamflatin compounds, have been synthesised to enable evaluation of the impact of varying the linking section on histone deacetylase inhibition. Preliminary testing indicates treatment of leukaemia cells with each of the analogues leads to significant inhibition of histone deacetylase and reduction in cell growth and proliferation.

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