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. 1990 Dec;5(6):767-71.
doi: 10.1016/0896-6273(90)90335-d.

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

R MacKinnon  1 , L Heginbotham, T Abramson
Affiliations

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

R MacKinnon et al. Neuron. 1990 Dec.

Abstract

The Shaker K+ channel belongs to a family of structurally related voltage-activated cation channels that play a central role in cellular electrical signaling. By studying multiple site-directed mutants of the Shaker K+ channel, a region that forms the binding site for a pore-blocking scorpion toxin has been identified. The region contains a sequence that is highly conserved among cloned K+ channels and may contribute to the formation of the ion conduction pore.

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