Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006;10(5):R143.
doi: 10.1186/cc5063.

Intensive care unit-acquired Stenotrophomonas maltophilia: incidence, risk factors, and outcome

Saad Nseir  1 , Christophe Di Pompeo, Hélène Brisson, Florent Dewavrin, Stéphanie Tissier, Maimouna Diarra, Marie Boulo, Alain Durocher
Affiliations
Comparative Study

Intensive care unit-acquired Stenotrophomonas maltophilia: incidence, risk factors, and outcome

Saad Nseir et al. Crit Care. 2006.

Abstract

Introduction: The aim of this study was to determine incidence, risk factors, and impact on outcome of intensive care unit (ICU)-acquired Stenotrophomonas maltophilia.

Methods: This prospective observational case-control study, which was a part of a cohort study, was conducted in a 30-bed ICU during a three year period. All immunocompetent patients hospitalised >48 hours were eligible. Patients with non-fermenting Gram-negative bacilli (NF-GNB) at ICU admission were excluded. Patients without ICU-acquired S. maltophilia who developed an ICU-acquired NF-GNB other than S. maltophilia were also excluded. Screening (tracheal aspirate and skin, anal, and nasal swabs) for NF-GNB was performed in all patients at ICU admission and weekly. Univariate and multivariate analyses were performed to determine risk factors for ICU-acquired S. maltophilia and for ICU mortality.

Results: Thirty-eight (2%) patients developed an S. maltophilia ICU-acquired colonisation and/or infection and were all successfully matched with 76 controls. Chronic obstructive pulmonary disease (COPD) and duration of antibiotic treatment (odds ratio [OR] [95% confidence interval (CI)] = 9.4 [3 to 29], p < 0.001, and 1.4 [1 to 2.3], p = 0.001, respectively) were independently associated with ICU-acquired S. maltophilia. Mortality rate (60% versus 40%, OR [95% CI] = 1.3 [1 to 1.7, p = 0.037]), duration of mechanical ventilation (23 +/- 16 versus 7 +/- 11 days, p < 0.001), and duration of ICU stay (29 +/- 21 versus 15 +/- 17 days, p < 0.001) were significantly higher in cases than in controls. In addition, ICU-acquired infection related to S. maltophilia was independently associated with ICU mortality (OR [95% CI] = 2.8 [1 to 7.7], p = 0.044).

Conclusion: COPD and duration of antibiotic treatment are independent risk factors for ICU-acquired S. maltophilia. ICU-acquired S. maltophilia is associated with increased morbidity and mortality rates. ICU-acquired infection related to S. maltophilia is an independent risk factor for ICU mortality.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Profile of the study in this report. ICU, intensive care unit; NF-GNB, non-fermenting Gram-negative bacilli
See this image and copyright information in PMC

References

    1. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR, Payen D. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34:344–353. doi: 10.1097/01.CCM.0000194725.48928.3A. - DOI - PubMed
    1. Aloush V, Navon-Venezia S, Seigman-Igra Y, Cabili S, Carmeli Y. Multidrug-resistant Pseudomonas aeruginosa: risk factors and clinical impact. Antimicrob Agents Chemother. 2006;50:43–48. doi: 10.1128/AAC.50.1.43-48.2006. - DOI - PMC - PubMed
    1. Berthelot P, Grattard F, Mallaval FO, Ros A, Lucht F, Pozzetto B. Epidemiology of nosocomial infections due to Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia. Pathol Biol. 2005;53:341–348. doi: 10.1016/j.patbio.2004.09.006. - DOI - PubMed
    1. Nseir S, Ader F, Marquette CH, Durocher A. Impact of fluoroquinolone use on multidrug-resistant bacteria emergence. Pathol Biol. 2005;53:470–475. doi: 10.1016/j.patbio.2005.07.008. - DOI - PubMed
    1. Micek ST, Lloyd AE, Ritchie DJ, Reichley RM, Fraser VJ, Kollef MH. Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother. 2005;49:1306–1311. doi: 10.1128/AAC.49.4.1306-1311.2005. - DOI - PMC - PubMed

Publication types

LinkOut - more resources