Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure
- PMID: 17027369
- DOI: 10.1016/j.fertnstert.2006.02.107
Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure
Abstract
Mutational screening of the bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) genes in a population with premature ovarian failure (POF) identified no new mutations. However, three single nucleotide polymorphisms in the BMP15 gene, two in the 5' untranslated region (31T>G and 71C>G) and another in exon 1 (387G>A), were found to be common in both POF and control groups.
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