Review
doi: 10.1016/j.biocel.2006.08.016.
Epub 2006 Sep 14.
VISA--a pass to innate immunity
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- PMID: 17029998
- DOI: 10.1016/j.biocel.2006.08.016
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Review
VISA--a pass to innate immunity
Int J Biochem Cell Biol.
2007.
Abstract
Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.
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