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Clinical Trial
. 2007 Mar;78(3):318-20.
doi: 10.1136/jnnp.2006.089409. Epub 2006 Oct 9.

Patterns of reoccurrence of segmental dystonia after discontinuation of deep brain stimulation

E Grips  1 , C Blahak, H H Capelle, H Bäzner, R Weigel, O Sedlaczek, J K Krauss, J C Wöhrle
Affiliations
Clinical Trial

Patterns of reoccurrence of segmental dystonia after discontinuation of deep brain stimulation

E Grips et al. J Neurol Neurosurg Psychiatry. 2007 Mar.

Abstract

The pattern of reoccurrence of symptoms after discontinuation of deep brain stimulation (DBS) has not been systematically studied in dystonia. Eight patients (mean age (SD) 53.8 (14.4) years) with segmental dystonia at a mean follow-up of 11.3 (4.2) months were studied after implantation of bilateral DBS electrodes in the internal globus pallidus using a standard video protocol and clinical rating scales, immediately and at 2 and 4 h after switching off DBS. Dystonic signs returned sequentially, with a rapid worsening of phasic and a slower worsening of tonic dystonic components. In all patients, phasic dystonic features appeared within a few minutes, whereas the tonic elements of dystonia reoccurred with a more variable delay. Differential clinical effects when withdrawing DBS might reflect its influence on different pathophysiological mechanisms in dystonia.

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Conflict of interest statement

Competing interests: Joachim K Krauss is a consultant to Medtronic, Minneapolis.

References

    1. Krauss J K, Pohle T, Weber S.et al Bilateral stimulation of globus pallidus internus for treatment of cervical dystonia. Lancet 1999354837–838. - PubMed
    1. Loher T J, Pohle T, Krauss J K. Functional stereotactic surgery for treatment of cervical dystonia: review of the experience from the lesional era. Stereotact Funct Neurosurg 2004821–13. - PubMed
    1. Coubes P, Cif L, El Fertit H.et al Electrical stimulation of the globus pallidus internus in patients with primary generalized dystonia: long‐term results. J Neurosurg 2004101189–194. - PubMed
    1. Vidailhet M, Vercueil L, Houeto J L.et al Bilateral deep‐brain stimulation of the globus pallidus in primary generalized dystonia. N Engl J Med 2005352459–467. - PubMed
    1. Krauss J K, Yianni J, Loher T J.et al Deep brain stimulation for dystonia. J Clin Neurophysiol 20042118–30. - PubMed

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