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Comparative Study
. 1975 Sep;28(9):711-6.
doi: 10.1136/jcp.28.9.711.

Lobular carcinoma of the breast: a special variant of mucin-secreting carcinoma

A Gad, J G Azzopardi
Comparative Study

Lobular carcinoma of the breast: a special variant of mucin-secreting carcinoma

A Gad et al. J Clin Pathol. 1975 Sep.

Abstract

There is currently much speculation over the precise nature of lobular carcinoma in-situ of the breast and its significance. Histochemical study shows that it is rich in sialomucin. This has a characteristic intracellular distribution which distinghishes lobular carcinoma in-situ from cancerization of lobules. The same histochemical features are seen in the infiltrative phase of the tumour. These findings invalidate the concept that it is a myoepithelial-cell tumour. Practical applications of the distinctive pattern of mucin secretion are discussed.

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