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. 2006 Oct 10:5:29.
doi: 10.1186/1476-069X-5-29.

A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon

Myriam Fillion  1 , Donna Mergler, Carlos José Sousa Passos, Fabrice Larribe, Mélanie Lemire, Jean Rémy Davée Guimarães
Affiliations

A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon

Myriam Fillion et al. Environ Health. .

Abstract

Background: Fish is considered protective for coronary heart disease (CHD), but mercury (Hg) intake from fish may counterbalance beneficial effects. Although neurotoxic effects of methylmercury (MeHg) are well established, cardiovascular effects are still debated. The objective of the present study was to evaluate blood pressure in relation to Hg exposure and fish consumption among a non-indigenous fish-eating population in the Brazilian Amazon.

Methods: The study was conducted among 251 persons from six communities along the Tapajós River, a major tributary of the Amazon. Data was obtained for socio-demographic information, fish consumption, height and weight to determine body mass index (BMI), systolic and diastolic blood pressure, and Hg concentration in hair samples.

Results: Results showed that overall, systolic and diastolic blood pressure, were relatively low (mean: 113.9 mmHg +/- 14.6 and 73.7 mmHg +/- 11.0). Blood pressure was significantly associated with hair total Hg (H-Hg), age, BMI and gender. No association was observed between fish consumption and blood pressure, although there were significant inter-community differences. Logistic regression analyses showed that the Odds Ratio (OR) for elevated systolic blood pressure (> or = 130 mmHg) with H-Hg > or = 10 microg/g was 2.91 [1.26-7.28], taking into account age, BMI, smoking, gender and community.

Conclusion: The findings of this preliminary study add further support for Hg cardiovascular toxicity.

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Figures

Figure 1
Figure 1
Map of the study area
Figure 2
Figure 2
Scatter plot of systolic blood pressure (adjusted for covariates: age, sex, BMI, smoking and community) in relation to mercury exposure; regression line and 95% confidence interval (dotted lines)
See this image and copyright information in PMC

References

    1. Watanabe C, Satoh H. Evolution of our understanding of methylmercury as a health threat. Environ Health Perspec. 1996;104:367–378. - PMC - PubMed
    1. Mahaffey KR. Fish and shellfish as dietary sources of methylmercury and the omega-3 fatty acids, eicosahexaenoic acid and docosahexaenoic acid: risks and benefits. Environ Res. 2004;95:414–28. doi: 10.1016/j.envres.2004.02.006. - DOI - PubMed
    1. Clarkson TW, Magos L, Myers GJ. The toxicology of mercury current exposures and clinical manifestations. N Engl J Med. 2003;349:1731–1737. doi: 10.1056/NEJMra022471. - DOI - PubMed
    1. Guallar E, Sanz-Gallardo I, Van't Veer P, Bode P, Aro A, Gómez-Aracena J, Kark JD, Riemersma RA, Martín-Moreno JM, Kok FJ. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med. 2002;347:1747–1754. doi: 10.1056/NEJMoa020157. - DOI - PubMed
    1. Rissanen T, Voutilainen S, Nyyssönen K, Lakka TA, Salonen JT. Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events – The Kuopio Ischaemic Heart Disease Risk Factor Study. Circ. 2000;102:2677–2679. - PubMed

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