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Comparative Study
. 1991 Jan 15;88(2):537-41.
doi: 10.1073/pnas.88.2.537.

Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus

M F Flajnik  1 , C Canel, J Kramer, M Kasahara
Affiliations
Comparative Study

Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus

M F Flajnik et al. Proc Natl Acad Sci U S A. .

Abstract

Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like alpha-3 domain is more similar to the immunoglobulin-like domains of mammalian class II beta chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes is presented.

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References

    1. EMBO J. 1985 Nov;4(11):2839-47 - PubMed
    1. Nature. 1986 Oct 9-15;323(6088):540-3 - PubMed
    1. Comput Appl Biosci. 1990 Jul;6(3):237-45 - PubMed
    1. Nature. 1988 Sep 8;335(6186):167-70 - PubMed
    1. Immunogenetics. 1989;30(6):440-51 - PubMed

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