doi: 10.1126/science.1703324.
Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist
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- PMID: 1703324
- DOI: 10.1126/science.1703324
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Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist
Science.
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Abstract
CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK1 receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96,345 should be a useful tool for studying the action of substance P in the central nervous system.
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