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. 1991 Jan 25;251(4992):437-9.
doi: 10.1126/science.1703324.

Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist

S McLean  1 , A H Ganong, T F Seeger, D K Bryce, K G Pratt, L S Reynolds, C J Siok, J A Lowe 3rd, J Heym
Affiliations

Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist

S McLean et al. Science. .

Abstract

CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK1 receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96,345 should be a useful tool for studying the action of substance P in the central nervous system.

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