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. 1990;80(6):649-55.
doi: 10.1007/BF00307634.

Aluminium-induced tangles in cultured rat neurones. Enhanced effect of aluminium by addition of maltol

D Langui  1 , A Probst, B Anderton, J P Brion, J Ulrich
Affiliations

Aluminium-induced tangles in cultured rat neurones. Enhanced effect of aluminium by addition of maltol

D Langui et al. Acta Neuropathol. 1990.

Abstract

Neurofilamentous tangles have been induced in cultured neurones from rat brain hemispheres by application of both aluminium and maltol. Quantitative evaluation revealed a significantly higher percentage of tangle containing neurones when using the aluminium-maltol mixture than after application of aluminium alone. Tangles were found to be consistently stained with monoclonal antibodies to neurofilament proteins but failed to react with polyclonal antibodies against microtubule-associated proteins 1, 2 and tau.

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