Production of interferon by immune lymphocytes exposed to herpes simplex virus-antibody complexes
- PMID: 170341
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Production of interferon by immune lymphocytes exposed to herpes simplex virus-antibody complexes
J Immunol.
1975 Nov.
Abstract
Splenic leukocytes from rabbits immunized with herpes simplex virus (HSV) incorporated significant amounts of 3H-TdR and produced interferon after in vitro incubation with HSV antigens. In contrast, splenic leukocytes from nonimmune rabbits did not incorporate 3H-TdR or produce interferon when incubated with HSV antigens. Antigen-antibody complexes consisting of HSV antigens and anti-HSV antibody also were capable of stimulating immune leukocytes to incorporate 3H-TdR and to produce interferon.
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